Evidence · Systematic review or meta-analysis
Beractant and poractant alfa in premature neonates with respiratory distress syndrome: a systematic review of real-world evidence studies and randomized controlled trials.
- Bronchopulmonary dysplasia
- Medical
- Pneumothorax and air leak
- Respiratory
- Respiratory distress syndrome and surfactant
This paper is from 2020, more than five years ago. Newer evidence may have been published since.
Summary
This systematic review compares two animal-derived surfactants, beractant and poractant alfa, for respiratory distress syndrome in preterm infants, drawing on both real-world evidence studies and randomised controlled trials. Four real-world studies were tabulated and fifteen RCTs were meta-analysed. No statistically significant differences between the two surfactants were found for death, bronchopulmonary dysplasia, pneumothorax or air leak. Study designs, populations and follow-up varied widely.
Summary written for NICUlearn. Always read the original.
- Licence:
- Open (Creative Commons)
The full text of this openly licensed paper is available to NICUlearn members, and Neeky can answer questions from it.
Guidelines are shown for education. Follow your unit's own guidance and senior advice.