Evidence · Research paper
How well does neonatal neuroimaging correlate with neurodevelopmental outcomes in infants with hypoxic-ischemic encephalopathy?
- Communicating with families
- Hypoxic-ischaemic encephalopathy and cooling
- Medical
- Neurodevelopmental follow-up
- Neurology
Summary
Secondary analysis of 451 infants with hypoxic-ischaemic encephalopathy enrolled in a randomised trial, examining how MRI and MR spectroscopy at 4-6 days relate to death or neurodevelopmental impairment at 2 years. Severe brain injury, higher MRI injury scores and raised lactate/NAA ratio were associated with worse outcomes. Infants with mild or moderate MRI injury had Bayley-III scores similar to those without injury, so imaging discriminated poorly outside severe injury. The authors highlight the need to counsel families about a range of possible outcomes.
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- Licence:
- Open (Creative Commons)
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