Evidence · Systematic review or meta-analysis
Factors influencing necrotizing enterocolitis in premature infants in China: a systematic review and meta-analysis.
- Anaemia and transfusion
- Breast milk and breastfeeding
- Cardiovascular
- Congenital heart disease
- Late-onset sepsis
- Medical
- Necrotising enterocolitis
- Nursing
- Nutrition and gastrointestinal
Summary
This systematic review and meta-analysis of observational studies from China (8616 preterm infants) examines risk and protective factors for necrotising enterocolitis. Sixteen risk factors were identified, including septicaemia, blood transfusion, asphyxia, infection, congenital heart disease, respiratory distress syndrome, PDA, mechanical ventilation, severe anaemia, antibiotic exposure and maternal factors such as gestational diabetes and intrahepatic cholestasis of pregnancy. Breastfeeding, oral probiotics and antenatal glucocorticoids were associated with reduced risk. The authors note that the quality and quantity of included studies limit the conclusions and that further high-quality research is needed.
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- Open (Creative Commons)
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