Evidence · Systematic review or meta-analysis
Serum and urinary biomarkers to predict acute kidney injury in premature infants: a systematic review and meta-analysis of diagnostic accuracy.
- Acute kidney injury
- Medical
- Metabolic, endocrine and renal
Summary
This systematic review and meta-analysis of diagnostic accuracy evaluated serum and urinary biomarkers not in routine use for predicting acute kidney injury in premature infants. Fifteen studies including 791 infants were identified, covering 27 biomarkers such as serum cystatin C and urinary NGAL, osteopontin and KIM-1. Meta-analysis was only possible for urinary NGAL, which showed moderate sensitivity and specificity and good overall discriminative performance. The authors conclude that urinary NGAL shows promise as a diagnostic biomarker for AKI in preterm infants, while noting limitations of current creatinine- and urine output-based criteria.
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- Licence:
- Open (Creative Commons)
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