Evidence · Systematic review or meta-analysis
Short-term neonatal outcomes in women with gestational diabetes treated using metformin versus insulin: a systematic review and meta-analysis of randomized controlled trials.
- Growth
- Hypoglycaemia
- Medical
- Metabolic, endocrine and renal
Summary
Systematic review and meta-analysis of 24 randomised controlled trials (4355 participants) comparing metformin with insulin for gestational diabetes, focusing on short-term neonatal outcomes. Metformin was associated with lower birth weights compared with insulin, without an increased risk of short-term neonatal adverse outcomes. The authors suggest metformin may be useful for women at high risk of neonatal hypoglycaemia or who cannot use insulin safely. Relevant to perinatal teams counselling families and anticipating neonatal care of infants of diabetic mothers.
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- Licence:
- Open (Creative Commons)
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