Evidence · Systematic review or meta-analysis
Efficacy and Safety of Different Maintenance Doses of Caffeine Citrate for Treatment of Apnea in Premature Infants: A Systematic Review and Meta-Analysis.
- Apnoea of prematurity
- Medical
- Nursing
- Respiratory
This paper is from 2018, more than five years ago. Newer evidence may have been published since.
Summary
This systematic review and meta-analysis compares high versus low maintenance doses of caffeine citrate for treating apnoea of prematurity. It pooled thirteen randomised controlled trials involving 1515 preterm infants, drawing on English and Chinese databases and following Cochrane methods. Higher maintenance doses appeared more effective and comparably or more safe than lower doses, although tachycardia was more frequent. It is relevant to clinicians prescribing and monitoring caffeine therapy in neonatal units.
Summary written for NICUlearn. Always read the original.
- Licence:
- Open (Creative Commons)
The full text of this openly licensed paper is available to NICUlearn members, and Neeky can answer questions from it.
Guidelines are shown for education. Follow your unit's own guidance and senior advice.