Evidence · Systematic review or meta-analysis
Chorioamnionitis Is a Risk Factor for Intraventricular Hemorrhage in Preterm Infants: A Systematic Review and Meta-Analysis.
- Cardiovascular
- Early-onset sepsis
- Infection
- Intraventricular haemorrhage and white matter injury
- Medical
- Neurology
- Patent ductus arteriosus
This paper is from 2018, more than five years ago. Newer evidence may have been published since.
Summary
This systematic review and meta-analysis of 85 studies (over 46,000 preterm infants) examines whether exposure to chorioamnionitis is associated with intraventricular haemorrhage. Both clinical and histological chorioamnionitis were associated with increased risk of all grades of IVH, while funisitis did not add further risk. Chorioamnionitis-exposed infants were of lower gestational age and birth weight, but these differences did not appear to explain the IVH association. It is relevant to clinicians assessing perinatal risk factors for brain injury in very preterm infants.
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- Open (Creative Commons)
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