Evidence · Systematic review or meta-analysis
Interventions to minimize blood loss in very preterm infants-A systematic review and meta-analysis.
- Anaemia and transfusion
- Cord management
- Delivery room and stabilisation
- Jaundice and haematology
- Medical
- Nursing
- Preterm stabilisation
Summary
This systematic review and meta-analysis of 31 randomised trials (3,759 infants) evaluates interventions to minimise blood loss in very preterm infants, including placental transfusion strategies at birth and approaches that reduce or limit blood sampling. Delayed cord clamping or cord milking was associated with lower mortality, with moderate to low certainty of evidence. Evidence for other approaches, such as glucose monitoring devices, sampling from cord or placental blood, and blood reinfusion devices, was very limited and of very low certainty. The authors suggest future trials randomise infants to blood-saving approaches after placental transfusion.
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- Licence:
- Open (Creative Commons)
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