Evidence · Systematic review or meta-analysis
Risk Factors in Predicting Prognosis of Neonatal Bacterial Meningitis-A Systematic Review.
- Early-onset sepsis
- Infection
- Jaundice and haematology
- Late-onset sepsis
- Medical
- Neurodevelopmental follow-up
- Neurology
- Seizures
- Thrombocytopenia and bleeding
This paper is from 2018, more than five years ago. Newer evidence may have been published since.
Summary
This systematic review summarises prognostic factors that predict adverse outcomes in neonates with bacterial meningitis, drawing on 16 cohort and cross-sectional studies. Seizures and raised cerebrospinal fluid protein were the most consistent predictors of poor prognosis, with coma, need for ventilatory support and leukopenia also showing some predictive value. A bulging anterior fontanelle was associated with mortality. The authors note that no meta-analysis was performed and call for standardised follow-up protocols and better-designed prognostic studies.
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- Licence:
- Open (Creative Commons)
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