Evidence · Randomised trial
Prophylactic Oral Dextrose Gel for Newborn Babies at Risk of Neonatal Hypoglycaemia: A Randomised Controlled Dose-Finding Trial (the Pre-hPOD Study).
- Hypoglycaemia
- Medical
- Metabolic, endocrine and renal
- Nursing
- Postnatal and transitional care
- Transitional care
This paper is from 2016, more than five years ago. Newer evidence may have been published since.
Summary
Randomised, double-blind, placebo-controlled dose-finding trial conducted at two New Zealand hospitals assessing prophylactic buccal 40% dextrose gel in newborns at risk of hypoglycaemia (infants of diabetic mothers, late preterm, small or large for gestational age) who did not require NICU admission. Several dose regimens were compared with placebo, given as either a single dose at 1 hour or with additional pre-feed doses. The authors conclude that a single dose of 200 mg/kg reduced the incidence of neonatal hypoglycaemia. The trial informed the larger hPOD trial examining NICU admission and later outcomes.
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- Licence:
- Open (Creative Commons)
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