Evidence · Systematic review or meta-analysis
A Meta-Analysis of the Risk Factors of Persistent Pulmonary Hypertension in Newborns.
Systematic review or meta-analysisFrontiers in Pediatrics2021Full text
- Cardiovascular
- Medical
- Persistent pulmonary hypertension
- Respiratory
Summary
This meta-analysis of 22 studies (7,937 cases and over 2.6 million controls) examines maternal and neonatal risk factors for persistent pulmonary hypertension of the newborn. Twelve risk factors were assessed, seven maternal and five neonatal. The strongest associations were maternal smoking during pregnancy, gestation under 37 weeks and perinatal asphyxia. It aims to inform clinical prevention and early recognition of PPHN.
Summary written for NICUlearn. Always read the original.
- Licence:
- Open (Creative Commons)
The full text of this openly licensed paper is available to NICUlearn members, and Neeky can answer questions from it.
Guidelines are shown for education. Follow your unit's own guidance and senior advice.