Evidence · Randomised trial
A novel human milk fortifier supports adequate growth in very low birth weight infants: a non-inferiority randomised controlled trial.
- Allied health
- Breast milk and breastfeeding
- Enteral feeding
- Growth
- Medical
- Necrotising enterocolitis
- Nursing
- Nutrition and gastrointestinal
Summary
Double-blind non-inferiority randomised controlled trial across nine European NICUs comparing a novel cow's milk-based human milk fortifier containing lipids (including DHA and arachidonic acid), higher protein and lower carbohydrate with a standard multicomponent fortifier in human milk-fed very preterm infants. The primary outcome was weight growth velocity over 21 days, which was non-inferior in the test group. Length, head circumference, Z-scores, feed tolerance and common morbidities including necrotising enterocolitis did not differ significantly. The authors conclude the novel fortifier supports adequate growth and appears safe and well tolerated.
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- Open (Creative Commons)
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