Evidence · Systematic review or meta-analysis
Antenatal corticosteroids for impending late preterm (34-36+6 weeks) deliveries-A systematic review and meta-analysis of RCTs.
- CPAP and high flow
- Delivery room and stabilisation
- Hypoglycaemia
- Medical
- Metabolic, endocrine and renal
- Neurodevelopmental follow-up
- Respiratory
- Respiratory distress syndrome and surfactant
Summary
Systematic review and meta-analysis of seven randomised controlled trials examining neonatal outcomes after antenatal corticosteroid exposure for impending late preterm birth at 34 to 36+6 weeks' gestation. Primary outcomes were need for respiratory support or oxygen and neonatal hypoglycaemia, with secondary outcomes including RDS, transient tachypnoea, delivery room resuscitation, NICU admission, mortality and development. Moderate quality evidence suggested reduced need for respiratory support but an increased risk of hypoglycaemia in exposed late preterm infants. The authors call for large trials with neurodevelopmental follow-up, noting most included trials were from non-high-income settings.
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- Licence:
- Open (Creative Commons)
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