Evidence · Systematic review or meta-analysis
Association of Histological and Clinical Chorioamnionitis With Neonatal Sepsis Among Preterm Infants: A Systematic Review, Meta-Analysis, and Meta-Regression.
- Early-onset sepsis
- Infection
- Late-onset sepsis
- Medical
This paper is from 2020, more than five years ago. Newer evidence may have been published since.
Summary
This systematic review and meta-analysis of 107 studies examines the association between clinical and histological chorioamnionitis and neonatal sepsis in preterm infants. It analyses early onset, late onset and unspecified onset sepsis, distinguishing culture-proven from clinical sepsis, and considers the role of funisitis. Chorioamnionitis was associated with early onset sepsis and, to a lesser extent, culture-proven late onset sepsis. Meta-regression suggests the association with late onset sepsis may be mediated by the lower gestational age of exposed infants.
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- Licence:
- Open (Creative Commons)
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