Evidence · Systematic review or meta-analysis
Platelet transfusions in preterm infants: current concepts and controversies-a systematic review and meta-analysis.
- Anaemia and transfusion
- Infection
- Intraventricular haemorrhage and white matter injury
- Jaundice and haematology
- Late-onset sepsis
- Medical
- Necrotising enterocolitis
- Neurology
- Nutrition and gastrointestinal
- Thrombocytopenia and bleeding
Summary
Systematic review and meta-analysis of randomised and observational studies examining platelet transfusion in thrombocytopenic preterm infants, compared with no transfusion, different platelet count thresholds, or single versus multiple transfusions. Thirteen studies were included, assessing mortality, major bleeding including intraventricular haemorrhage, sepsis and necrotising enterocolitis. Platelet transfusion was associated with higher mortality, sepsis and NEC, while heterogeneity prevented firm conclusions on IVH. The authors highlight the lack of consensus transfusion criteria and the need for further studies to define safer thresholds.
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