Evidence · Systematic review or meta-analysis
Weaning strategies for the withdrawal of non-invasive respiratory support applying continuous positive airway pressure in preterm infants: a systematic review and meta-analysis.
- Bronchopulmonary dysplasia
- CPAP and high flow
- Medical
- Nursing
- Respiratory
This paper is from 2020, more than five years ago. Newer evidence may have been published since.
Summary
Systematic review and meta-analysis of 15 randomised trials (1,547 infants) comparing strategies for weaning preterm infants born before 37 weeks from non-invasive respiratory support with nasal CPAP or high-flow nasal cannula. It compares gradual pressure weaning, sudden discontinuation, stepdown to nasal cannula and interval training. Gradual pressure weaning may improve first-attempt success, stepdown to nasal cannula allowed earlier weaning but longer oxygen supplementation, and interval training showed no benefit. No strategy affected chronic lung disease or length of hospital stay.
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- Licence:
- Open (Creative Commons)
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