Evidence · Randomised trial
Hypotension in Preterm Infants (HIP) randomised trial.
- Cardiovascular
- Intraventricular haemorrhage and white matter injury
- Medical
- Neurology
- Shock and hypotension
Summary
The HIP trial was a double-blind, placebo-controlled randomised trial across 10 European and Canadian sites. It compared standard management (saline bolus then dopamine) with restrictive management (saline bolus then placebo) for low blood pressure in the first 72 hours in infants born before 28 weeks' gestation. The primary outcome was survival to 36 weeks' postmenstrual age without severe brain injury. The trial stopped early with only 58 infants enrolled and found no major outcome differences, although it lacked power to detect them.
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