Evidence · Randomised trial
Sustained inflation and chest compression versus 3:1 chest compression to ventilation ratio during cardiopulmonary resuscitation of asphyxiated newborns (SURV1VE): A cluster randomised controlled trial.
- Delivery room and stabilisation
- Ethics
- Families and professional practice
- Medical
- Newborn life support
- Nursing
Summary
International multicentre cluster cross-over randomised trial in four hospitals in Canada and Austria comparing continuous chest compressions with superimposed sustained inflation (CC+SI) against the standard 3:1 compression to ventilation ratio in newborns over 28 weeks' gestation needing chest compressions in the delivery room. The primary outcome was time to return of spontaneous circulation. The trial was stopped early with only 27 infants randomised, owing to ethics approval, insurance and funding issues. No statistically significant differences in time to ROSC or mortality were found, though the study was underpowered.
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- Open (Creative Commons)
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