Evidence · Systematic review or meta-analysis
Surfactant therapy and antibiotics in neonates with meconium aspiration syndrome: a systematic review and meta-analysis.
- Early-onset sepsis
- Infection
- Mechanical ventilation
- Meconium aspiration
- Medical
- Respiratory
- Respiratory distress syndrome and surfactant
This paper is from 2016, more than five years ago. Newer evidence may have been published since.
Summary
This systematic review and meta-analysis evaluates surfactant, given as lung lavage or bolus, and antibiotics in neonates with meconium aspiration syndrome. Eight surfactant studies and three antibiotic studies were included. Surfactant by either method shortened mechanical ventilation and hospital stay without a clear effect on mortality, and bolus surfactant reduced the need for ECMO. Antibiotics showed no significant benefit in neonates without evidence of sepsis, and the authors call for further evidence before routine use.
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- Licence:
- Open (Creative Commons)
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