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Evidence · Research paper

Cost-effectiveness of strategies preventing late-onset infection in preterm infants.

Research paperArchives of Disease in Childhood2020Over 5 years oldFull text
  • Comfort and nursing care
  • Infection
  • Infection prevention
  • Late-onset sepsis
  • Line and device care
  • Medical
  • Neurodevelopmental follow-up
  • Nursing

This paper is from 2020, more than five years ago. Newer evidence may have been published since.

Summary

Model-based cost-effectiveness analysis of interventions to prevent late-onset infection in UK preterm infants born at or before 32 weeks requiring a PICC, using PREVAIL trial data linked to routine NHS data. It estimates lifetime health losses and costs associated with neurodevelopmental impairment and late-onset infection. Antimicrobial-impregnated PICCs were more costly with negligible health benefit compared with standard PICCs and are unlikely to be cost-effective, while even modestly effective infection-prevention strategies may be cost-effective.

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