Evidence · Systematic review or meta-analysis
Glycemic control and neonatal outcomes in women with gestational diabetes mellitus treated using glyburide, metformin, or insulin: a pairwise and network meta-analysis.
- Growth
- Hypoglycaemia
- Medical
- Metabolic, endocrine and renal
Summary
This pairwise and network meta-analysis of 23 randomised trials (4533 women) compares glyburide, metformin and insulin for treating gestational diabetes. It examines maternal glycaemic control alongside neonatal outcomes including neonatal hypoglycaemia and birth weight, as well as maternal weight gain and pre-eclampsia. Metformin appeared at least as effective as insulin for glycaemic control and was associated with less neonatal hypoglycaemia and lower birth weight. It is mainly relevant to obstetric management, with implications for anticipating risk in infants of diabetic mothers.
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- Licence:
- Open (Creative Commons)
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