Evidence · Research paper
Neonatal pulmonary hypertension after severe early-onset fetal growth restriction: post hoc reflections on the Dutch STRIDER study.
- Bronchopulmonary dysplasia
- Cardiovascular
- Medical
- Persistent pulmonary hypertension
- Respiratory
Summary
Post hoc analysis of the Dutch STRIDER trial, in which pregnant women with severe early-onset fetal growth restriction were randomised to antenatal sildenafil or placebo. It examines the definition, prevalence, timing and possible pathophysiology of neonatal pulmonary hypertension, distinguishing early PPHN from pulmonary hypertension associated with sepsis or bronchopulmonary dysplasia. Pulmonary hypertension was more frequent after antenatal sildenafil exposure, with rebound vasoconstriction proposed as a mechanism. The authors call for a consensus definition and standardised screening of at-risk infants.
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- Licence:
- Open (Creative Commons)
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