Evidence · Systematic review or meta-analysis
Active versus restrictive approach to isolated hypotension in preterm neonates: A Systematic Review, Meta-analysis and GRADE based Clinical Practice Guideline.
- Cardiovascular
- Eyes and hearing
- Intraventricular haemorrhage and white matter injury
- Medical
- Neurodevelopmental follow-up
- Neurology
- Newborn hearing screening
- Shock and hypotension
Summary
Systematic review and meta-analysis with a GRADE-based guideline comparing active versus restrictive management of isolated hypotension (without signs of poor perfusion) in very preterm infants. It included 44 randomised and non-randomised studies, assessing mortality, major brain injury and neurodevelopmental impairment at 18-24 months corrected age. The authors suggest isolated hypotension may not need treatment in the first 24 hours, whereas treatment may be considered between 24 and 72 hours, though evidence certainty was very low.
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- Open (Creative Commons)
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