Evidence · Research paper
Development and validation of a risk prediction model of preterm birth for women with preterm labour symptoms (the QUIDS study): A prospective cohort study and individual participant data meta-analysis.
- Delivery room and stabilisation
- Ethics
- Families and professional practice
- Medical
Summary
The QUIDS study developed and validated a risk prediction model for spontaneous preterm birth within 7 days in women at 22 to 34 weeks' gestation presenting with symptoms of preterm labour. The model combines quantitative vaginal fetal fibronectin with clinical risk factors (smoking, ethnicity, nulliparity, multiple pregnancy). It was developed using an individual participant data meta-analysis of European cohorts and externally validated in a UK multicentre prospective cohort, with an accompanying cost-effectiveness analysis. It is primarily obstetric but relevant to neonatal teams preparing for anticipated preterm deliveries.
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- Open (Creative Commons)
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