Evidence · Systematic review or meta-analysis
Clinical characteristics of severe neonatal enterovirus infection: a systematic review.
- Congenital infections
- Infection
- Late-onset sepsis
- Mechanical ventilation
- Medical
- Respiratory
Summary
This systematic review pools 237 published cases of severe neonatal enterovirus infection reported between 2000 and 2020. It describes presenting features such as temperature instability, rash, poor feeding and respiratory symptoms, and major complications including hepatitis with coagulopathy, myocarditis and meningoencephalitis. Lethality was high, particularly with myocarditis. It also summarises supportive treatments, including blood products, IVIG, ventilation and ECMO, and limited antiviral use with pleconaril and pocapavir.
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- Licence:
- Open (Creative Commons)
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