Evidence · Other
Surfactant therapies for pediatric and neonatal ARDS: ESPNIC expert consensus opinion for future research steps.
- Mechanical ventilation
- Medical
- Respiratory
- Respiratory distress syndrome and surfactant
Summary
Expert consensus from the European Society for Paediatric and Neonatal Intensive Care reviewing preclinical and clinical evidence on surfactant therapy for paediatric (PARDS) and neonatal (NARDS) acute respiratory distress syndrome. It notes that existing trials were heterogeneous in patient characteristics, surfactant type and administration strategy, and largely predated current definitions. Four consensus statements address future research: targeted studies using current definitions, treating PARDS and NARDS as syndromes stratified by key characteristics, preferring explanatory trial designs, and choosing outcomes suited to trial phase and population. It is a research agenda rather than clinical practice guidance.
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- Open (Creative Commons)
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