Evidence · Randomised trial
Effectiveness of intratracheal salbutamol in addition to surfactant on the clinical course of newborns with respiratory distress syndrome: a clinical trial.
- CPAP and high flow
- Mechanical ventilation
- Medical
- Pneumothorax and air leak
- Respiratory
- Respiratory distress syndrome and surfactant
This paper is from 2016, more than five years ago. Newer evidence may have been published since.
Summary
A blinded randomised trial in a level III NICU of 48 preterm infants with respiratory distress syndrome, comparing intratracheal salbutamol with normal saline given alongside surfactant via the INSURE approach. The primary outcome was INSURE failure; secondary outcomes included duration of CPAP, ventilation and oxygen therapy, complications such as PDA and pneumothorax, mortality and length of stay. INSURE failure was not significantly different between groups, though hospital stay was shorter with salbutamol. The authors suggest salbutamol may improve the clinical course, but the small sample limits conclusions.
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- Open (Creative Commons)
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