Evidence · Systematic review or meta-analysis
Inborn errors of metabolism in neonates and pediatrics on varying dialysis modalities: a systematic review and meta-analysis.
- Acute kidney injury
- Inborn errors of metabolism
- Medical
- Metabolic, endocrine and renal
Summary
This systematic review and meta-analysis of 37 observational studies (642 patients) compares continuous kidney replacement therapy, haemodialysis and peritoneal dialysis in neonates and children with inborn errors of metabolism causing hyperammonaemia or raised leucine. Outcomes were mortality, percentage reduction in ammonia and time to halve ammonia levels. Continuous KRT showed a trend towards lower mortality and may reduce rebound hyperammonaemia and improve haemodynamic stability, while all modalities reduced ammonia and leucine comparably. Higher pre-treatment ammonia was associated with greater mortality.
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- Licence:
- Open (Creative Commons)
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