Evidence · Randomised trial
Caffeine to prevent intermittent hypoxaemia in late preterm infants: randomised controlled dosage trial.
- Apnoea of prematurity
- Medical
- Nursing
- Respiratory
Summary
Phase IIB double-blind five-arm randomised controlled trial from two tertiary maternity hospitals in New Zealand, comparing enteral caffeine citrate dosing regimens with placebo in late preterm infants born at 34+0 to 36+6 weeks' gestation. The primary outcome was intermittent hypoxaemia two weeks after randomisation. Caffeine reduced intermittent hypoxaemia compared with placebo, and the highest dose studied was the most effective. The trial informs dose selection for future larger trials of caffeine in this population.
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- Open (Creative Commons)
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