Evidence · Randomised trial
Early versus late parenteral nutrition in term and late preterm infants: a randomised controlled trial.
- Allied health
- Growth
- Medical
- Metabolic, endocrine and renal
- Nutrition and gastrointestinal
- Parenteral nutrition
Summary
Single-centre exploratory randomised controlled trial comparing early (day 1-2) versus late (day 6) parenteral nutrition in term and late preterm infants (≥34 weeks) admitted to a level-3 neonatal unit in a paediatric hospital. Primary outcomes were plasma phenylalanine and F2-isoprostane (oxidative stress) levels, with amino-acid and fatty-acid profiles and clinical outcomes as secondary measures. Early PN produced transiently higher phenylalanine and more hyperglycaemia but less postnatal weight growth restriction, without clear differences in oxidative stress. The authors call for further investigation of clinical effects.
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- Open (Creative Commons)
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