Evidence · Research paper
Adherence to World Health Organisation guidelines for treatment of early onset neonatal sepsis in low-income settings; a cohort study in Nepal.
- Early-onset sepsis
- Families and professional practice
- Infection
- Medical
- Quality improvement
This paper is from 2020, more than five years ago. Newer evidence may have been published since.
Summary
Cohort study of 1564 infants with suspected early onset sepsis (onset within 72 hours) across 12 regional hospitals in Nepal, assessing adherence to WHO first-line antibiotic guidelines. About three-quarters were treated according to guidelines, with adherence rising over time and higher in larger facilities, inborn infants and families of disadvantaged caste. Cefotaxime was a common alternative when guidelines were not followed, raising concerns about antimicrobial resistance. Relevant to antimicrobial stewardship and sepsis care in low-resource settings.
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- Open (Creative Commons)
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