Evidence · Research paper
Acute Kidney Injury Defined by Fluid-Corrected Creatinine in Premature Neonates: A Secondary Analysis of the PENUT Randomized Clinical Trial.
- Acute kidney injury
- Bronchopulmonary dysplasia
- Fluids and electrolytes
- Mechanical ventilation
- Medical
- Metabolic, endocrine and renal
- Respiratory
Summary
Post hoc cohort analysis of the PENUT trial examining whether correcting serum creatinine for fluid balance changes acute kidney injury diagnosis in extremely preterm neonates born before 28 weeks. Fluid correction reclassified many infants, increasing AKI prevalence from about 23% to 34%. Fluid-corrected AKI was associated with greater odds of mechanical ventilation at day 14 and severe bronchopulmonary dysplasia, and longer hospital stay. The authors suggest future studies consider fluid-corrected creatinine when defining neonatal AKI.
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