Evidence · Systematic review or meta-analysis
Pulmonary Hypertension Association with Mortality in Newborns with Giant Omphalocele: A Systematic Review and Meta-Analysis.
- Abdominal wall defects
- Cardiovascular
- Mechanical ventilation
- Medical
- Persistent pulmonary hypertension
- Respiratory
- Surgical conditions
Summary
This systematic review and meta-analysis examines the association between pulmonary hypertension and mortality in newborns with giant omphalocele. It pooled five retrospective cohorts totalling 258 infants and assessed secondary outcomes including duration of mechanical ventilation, NICU and hospital length of stay, parenteral nutrition, tracheostomy, high-frequency ventilation and home oxygen. Pulmonary hypertension was associated with higher mortality and prolonged mechanical ventilation. The authors call for further work on risk factors and targeted management strategies.
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- Open (Creative Commons)
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