Evidence · Randomised trial
Analgesic efficacy and safety of morphine in the Procedural Pain in Premature Infants (Poppi) study: randomised placebo-controlled trial.
- Comfort and nursing care
- Eyes and hearing
- Medical
- Nursing
- Pain and comfort
- Retinopathy of prematurity
This paper is from 2018, more than five years ago. Newer evidence may have been published since.
Summary
Single-centre randomised placebo-controlled trial (Poppi) in Oxford assessing oral morphine for procedural pain in non-ventilated premature infants born before 32 weeks or under 1501 g, studied at 34-42 weeks' gestational age. Infants received morphine or placebo before heel lance and retinopathy of prematurity screening, with pain assessed by PIPP-R and noxious-evoked brain activity. The trial stopped early because of respiratory adverse effects with no evidence of analgesic benefit. Authors advise against oral morphine for ROP screening and urge caution for other acute procedures in non-ventilated preterm infants.
Summary written for NICUlearn. Always read the original.
- Licence:
- Open (Creative Commons)
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