Evidence · Systematic review or meta-analysis
Risk factors for severe neonatal hyperbilirubinemia in low and middle-income countries: a systematic review and meta-analysis.
- Jaundice and haematology
- Jaundice and phototherapy
- Medical
- Nursing
This paper is from 2015, more than five years ago. Newer evidence may have been published since.
Summary
This systematic review and meta-analysis identifies maternal and infant risk factors for severe neonatal hyperbilirubinaemia in low- and middle-income countries, pooling 13 studies from India, Nigeria, Pakistan, Nepal and Egypt. Risk factors identified include primiparity, delivery outside public hospitals, ABO and Rhesus haemolytic disease, G6PD deficiency, UGT1A1 polymorphisms, lower gestational age, weight loss, sepsis and high bilirubin levels. Low social class was not associated with increased risk. The authors highlight that many contributing factors are amenable to existing interventions to reduce the burden of disease.
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- Licence:
- Open (Creative Commons)
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