Evidence · Systematic review or meta-analysis
Intestinal dysbiosis in preterm infants preceding necrotizing enterocolitis: a systematic review and meta-analysis.
- Medical
- Necrotising enterocolitis
- Nutrition and gastrointestinal
This paper is from 2017, more than five years ago. Newer evidence may have been published since.
Summary
This systematic review and meta-analysis examines stool microbiome profiles in preterm infants before the onset of necrotising enterocolitis, pooling 14 studies with reprocessed 16S rRNA data from eight (106 NEC cases, 278 controls). Dysbiosis preceding NEC was characterised by increased Proteobacteria and decreased Firmicutes and Bacteroidetes, without consistent differences in alpha- or beta-diversity. Taxonomic profiles varied with antibiotic exposure, formula feeding and mode of delivery, and heterogeneity related to study and sequencing region. The authors suggest microbiome optimisation as a potential NEC prevention strategy.
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- Licence:
- Open (Creative Commons)
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