Evidence · Systematic review or meta-analysis
Vitamin A to prevent bronchopulmonary dysplasia in extremely low birth weight infants: a systematic review and meta-analysis.
- Bronchopulmonary dysplasia
- Eyes and hearing
- Medical
- Nutrition and gastrointestinal
- Respiratory
- Retinopathy of prematurity
This paper is from 2018, more than five years ago. Newer evidence may have been published since.
Summary
This systematic review and meta-analysis of four randomised trials (1,011 infants) examines vitamin A supplementation for preventing bronchopulmonary dysplasia in extremely low birth weight infants. Vitamin A was given intramuscularly in most trials and orally in one. It found a modest reduction in oxygen dependency at 36 weeks' postmenstrual age (moderate certainty), but no reduction in neonatal death, IVH, ROP or NEC. Evidence certainty was assessed using GRADE.
Summary written for NICUlearn. Always read the original.
- Licence:
- Open (Creative Commons)
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