Evidence · Randomised trial
Intravenous paracetamol in comparison with ibuprofen for the treatment of patent ductus arteriosus in preterm infants: a randomized controlled trial.
- Cardiovascular
- Medical
- Patent ductus arteriosus
Summary
Multicentre randomised controlled trial comparing intravenous paracetamol with intravenous ibuprofen for haemodynamically significant patent ductus arteriosus in preterm infants of 25 to 31 weeks' gestation. Paracetamol achieved a lower ductal closure rate after the first course than ibuprofen, but ductal constriction rates were similar. Re-opening, need for surgical closure and adverse effects did not differ between groups. The authors suggest the findings support intravenous paracetamol as a first-choice option for hsPDA treatment.
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- Licence:
- Open (Creative Commons)
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