Evidence · Systematic review or meta-analysis
Less invasive surfactant administration versus intubation-surfactant-extubation in the treatment of neonatal respiratory distress syndrome: a systematic review and meta-analyses.
- Bronchopulmonary dysplasia
- CPAP and high flow
- Intraventricular haemorrhage and white matter injury
- Mechanical ventilation
- Medical
- Neurology
- Nursing
- Pneumothorax and air leak
- Respiratory
- Respiratory distress syndrome and surfactant
Summary
This systematic review and meta-analysis compares less invasive surfactant administration (LISA) with intubation-surfactant-extubation (INSURE) in preterm infants with respiratory distress syndrome. It pooled sixteen randomised controlled trials published between 2012 and 2020, including 1,944 preterm infants. Outcomes included duration of mechanical ventilation and CPAP, cerebral oxygenation, pneumothorax, peri-intraventricular haemorrhage, BPD and mortality. The authors conclude that LISA offers benefits over INSURE across several of these outcomes.
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- Licence:
- Open (Creative Commons)
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