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Evidence · Systematic review or meta-analysis

Association between Congenital Cytomegalovirus Infection and Brain Injury in Neonates: A Meta-analysis of Cohort Studies.

Systematic review or meta-analysisBehavioural neurology2021Full text
  • Congenital infections
  • Eyes and hearing
  • Infection
  • Medical
  • Neurodevelopmental follow-up
  • Neurology
  • Newborn hearing screening

Summary

Meta-analysis of 13 cohort studies including 4,262 neonates with congenital cytomegalovirus infection, assessing associations with brain injury outcomes. Infected neonates had higher rates of hearing impairment, sensorineural hearing loss and microcephaly compared with controls. The authors highlight the need for neonatal screening programmes and comprehensive diagnostic testing to identify infection early and improve prognosis. Relevant to clinicians involved in diagnosis, screening and follow-up of congenital CMV.

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