Guidelines and research
Official guidance for neonatal care, the evidence behind it, and the latest neonatal research.
Open-access systematic reviews, meta-analyses and trials on neonatal topics, chosen for relevance and how widely they are cited. Evidence informs guidance but doesn't replace it.
- Extended Barrier Precautions vs Hand Hygiene Alone and Neonatal Sepsis in Intensive Care Patients: The BALTIC Cluster-Randomized Clinical Trial.Randomised trialJAMA Network Open2026Full text
- Development and implementation of educational modules on management of neonates with critical congenital heart disease in the delivery room (LEARN-CHD).Randomised trialJournal of Perinatology2026Full text
- Randomised crossover trial of neurally adjusted ventilatory assist (NAVA) for neonates with congenital diaphragmatic hernias: the NAN-C study.Randomised trialEuropean Journal of Pediatrics2026Full text
- Octenidine or Sterile Water Cleansing and Late-Onset Sepsis in Neonates in the NICU: A Randomized Clinical Trial.Randomised trialJAMA Network Open2026Full text
- Platelet characteristics in extremely preterm infants after fatty acid supplementation: a randomized controlled trial.Randomised trialPediatric Research2025Full text
- The efficiency and safety of low-dose intravenous indomethacin for closure of patent ductus arteriosus in preterm neonate: a randomized controlled trial.Randomised trialScientific Reports2025Full text
- Real-time ultrasound to assess the umbilical catheter position in neonates: a randomized, controlled trial.Randomised trialJournal of Perinatology2025Full text
- A novel human milk fortifier supports adequate growth in very low birth weight infants: a non-inferiority randomised controlled trial.Randomised trialArchives of Disease in Childhood. Fetal and Neonatal Edition2025Full text
- Early versus late parenteral nutrition in term and late preterm infants: a randomised controlled trial.Randomised trialBMJ Paediatrics Open2024Full text
- Sustained inflation and chest compression versus 3:1 chest compression to ventilation ratio during cardiopulmonary resuscitation of asphyxiated newborns (SURV1VE): A cluster randomised controlled trial.Randomised trialArchives of Disease in Childhood: Fetal and Neonatal Edition2024Full text
- Clonidine as Monotherapy for Neonatal Opioid Withdrawal Syndrome: A Randomized Trial.Randomised trialPediatrics2024Full text
- Ventilatory Assistance Before Umbilical Cord Clamping in Extremely Preterm Infants: A Randomized Clinical Trial.Randomised trialJAMA Network Open2024Full text
- Effectiveness of kangaroo mother care before clinical stabilisation versus standard care among neonates at five hospitals in Uganda (OMWaNA): a parallel-group, individually randomised controlled trial and economic evaluation.Randomised trialLancet2024Full text
- Joint observation in NICU (JOIN): A randomized controlled trial testing an early, one-session intervention during preterm care to improve perceived maternal self-efficacy and other mental health outcomes.Randomised trialPLOS ONE2024Full text
- Cord blood transfusions in extremely low gestational age neonates to reduce severe retinopathy of prematurity: results of a prespecified interim analysis of the randomized BORN trial.Randomised trialItalian journal of pediatrics2024Full text
- Azygos vein preservation revisited: impact on early outcomes after repair of esophageal atresia/tracheoesophageal fistula in newborns.Randomised trialUpdates in Surgery2023Full text
- A Pilot Phase I Trial of Allogeneic Umbilical Cord Tissue-Derived Mesenchymal Stromal Cells in Neonates With Hypoxic-Ischemic Encephalopathy.Randomised trialStem cells translational medicine2023Full text
- Enteral and Parenteral Treatment with Caffeine for Preterm Infants in the Delivery Room: A Randomised Trial.Randomised trialPaediatric Drugs2023Full text
- Caffeine to prevent intermittent hypoxaemia in late preterm infants: randomised controlled dosage trial.Randomised trialArchives of Disease in Childhood: Fetal and Neonatal Edition2023Full text
- Oropharyngeal colostrum administration in neonates with gastroschisis: a randomized clinical trial.Randomised trialCritical care science2023Full text
- Ultrasound-Guided Cannulation of the Great Saphenous Vein in Neonates: A Randomized Study.Randomised trialAmerican Journal of Perinatology2023Full text
- Early versus delayed enteral nutrition for neonatal hypoxic-ischemic encephalopathy undergoing therapeutic hypothermia: a randomized controlled trial.Randomised trialItalian Journal of Pediatrics2022Full text
- Source of human milk (mother or donor) is more important than fortifier type (human or bovine) in shaping the preterm infant microbiome.Randomised trialCell Reports Medicine2022Full text
- Morphine versus methadone for neonatal opioid withdrawal syndrome: a randomized controlled pilot study.Randomised trialBMC Pediatrics2022Full text
- Effect of a Multi-Strain Probiotic on Growth and Time to Reach Full Feeds in Preterm Neonates.Randomised trialNutrients2022Full text
- Rapid intrapartum test for maternal group B streptococcal colonisation and its effect on antibiotic use in labouring women with risk factors for early-onset neonatal infection (GBS2): cluster randomised trial with nested test accuracy study.Randomised trialBMC Medicine2022Full text
- Work of breathing at different tidal volume targets in newborn infants with congenital diaphragmatic hernia.Randomised trialEuropean Journal of Pediatrics2022Full text
- Randomised controlled trial of fosfomycin in neonatal sepsis: pharmacokinetics and safety in relation to sodium overload.Randomised trialArchives of Disease in Childhood2022Full text
- Oral versus intravenous sildenafil for pulmonary hypertension in neonates: a randomized trial.Randomised trialBMC Pediatrics2022Full text
- Effect of sunflower seed oil emollient therapy on newborn infant survival in Uttar Pradesh, India: A community-based, cluster randomized, open-label controlled trial.Randomised trialPLoS Medicine2021Full text
- Hypothermia for moderate or severe neonatal encephalopathy in low-income and middle-income countries (HELIX): a randomised controlled trial in India, Sri Lanka, and Bangladesh.Randomised trialThe Lancet Global Health2021Full text
- Immediate "Kangaroo Mother Care" and Survival of Infants with Low Birth Weight.Randomised trialThe New England Journal of Medicine2021Full text
- Oropharyngeal administration of colostrum for preventing necrotizing enterocolitis and late-onset sepsis in preterm infants with gestational age ≤ 32 weeks: a pilot single-center randomized controlled trial.Randomised trialInternational Breastfeeding Journal2021Full text
- Home phototherapy for hyperbilirubinemia in term neonates-an unblinded multicentre randomized controlled trial.Randomised trialEuropean Journal of Pediatrics2021Full text
- Efficacy of medium-chain triglyceride oil massage on growth in preterm infants: a randomized controlled trial: A CONSORT-compliant article.Randomised trialMedicine (journal)2021Full text
- Stem cells for bronchopulmonary dysplasia in preterm infants: A randomized controlled phase II trial.Randomised trialStem Cells Translational Medicine2021Full text
- Intravenous paracetamol in comparison with ibuprofen for the treatment of patent ductus arteriosus in preterm infants: a randomized controlled trial.Randomised trialEuropean Journal of Pediatrics2021Full text
- Hypotension in Preterm Infants (HIP) randomised trial.Randomised trialArchives of Disease in Childhood: Fetal and Neonatal Edition2021Full text
- BCG-induced non-specific effects on heterologous infectious disease in Ugandan neonates: an investigator-blind randomised controlled trial.Randomised trialThe Lancet Infectious Diseases2021Full text
- Effect of Treatment of Clinical Seizures vs Electrographic Seizures in Full-Term and Near-Term Neonates: A Randomized Clinical Trial.Randomised trialJAMA Network Open2021Full text
- Real-time continuous glucose monitoring in preterm infants (REACT): an international, open-label, randomised controlled trial.Randomised trialThe Lancet Child & Adolescent Health2021Full text
- Non-invasive duo positive airway pressure ventilation versus nasal continuous positive airway pressure in preterm infants with respiratory distress syndrome: a randomized controlled trial.Randomised trialBMC Pediatrics2021Full text
- Meropenem vs standard of care for treatment of neonatal late onset sepsis (NeoMero1): A randomised controlled trial.Randomised trialPLoS One2020Over 5 years oldFull text
- Creative Music Therapy with Premature Infants and Their Parents: A Mixed-Method Pilot Study on Parents' Anxiety, Stress and Depressive Symptoms and Parent-Infant Attachment.Randomised trialInternational Journal of Environmental Research and Public Health2020Over 5 years oldFull text
- A machine-learning algorithm for neonatal seizure recognition: a multicentre, randomised, controlled trial.Randomised trialThe Lancet Child & Adolescent Health2020Over 5 years oldFull text
- Family nurture intervention in the NICU increases autonomic regulation in mothers and children at 4-5 years of age: Follow-up results from a randomized controlled trial.Randomised trialPLOS ONE2020Over 5 years oldFull text
- The efficacy and safety of peripheral intravenous parenteral nutrition vs 10% glucose in preterm infants born 30 to 33 weeks' gestation: a randomised controlled trial.Randomised trialBMC Pediatrics2020Over 5 years oldFull text
- Treatment of opioid withdrawal in neonates with morphine, phenobarbital, or chlorpromazine: a randomized double-blind trial.Randomised trialEuropean Journal of Pediatrics2020Over 5 years oldFull text
- Effectiveness of Alberta Family Integrated Care on infant length of stay in level II neonatal intensive care units: a cluster randomized controlled trial.Randomised trialBMC Pediatrics2020Over 5 years oldFull text
- Effect of a quality improvement package for intrapartum and immediate newborn care on fresh stillbirth and neonatal mortality among preterm and low-birthweight babies in Kenya and Uganda: a cluster-randomised facility-based trial.Randomised trialThe Lancet Global Health2020Over 5 years oldFull text
- Physiological effects of high-flow nasal cannula therapy in preterm infants.Randomised trialArchives of Disease in Childhood: Fetal and Neonatal Edition2020Over 5 years oldFull text
- rhIGF-1/rhIGFBP-3 in Preterm Infants: A Phase 2 Randomized Controlled Trial.Randomised trialThe Journal of Pediatrics2019Over 5 years oldFull text
- Enteral lactoferrin supplementation for very preterm infants: a randomised placebo-controlled trial.Randomised trialLancet2019Over 5 years oldFull text
- Planned early delivery or expectant management for late preterm pre-eclampsia (PHOENIX): a randomised controlled trial.Randomised trialLancet (London, England)2019Over 5 years oldFull text
- No neurodevelopmental benefit of cerebral oximetry in the first randomised trial (SafeBoosC II) in preterm infants during the first days of life.Randomised trialActa Paediatrica2019Over 5 years oldFull text
- Effects of Lactobacillus reuteri DSM 17938 in preterm infants: a double-blinded randomized controlled study.Randomised trialItalian Journal of Pediatrics2019Over 5 years oldFull text
- Safety and pharmacokinetics of dolutegravir in pregnant mothers with HIV infection and their neonates: A randomised trial (DolPHIN-1 study).Randomised trialPLoS Medicine2019Over 5 years oldFull text
- Effect of a scaled-up neonatal resuscitation quality improvement package on intrapartum-related mortality in Nepal: A stepped-wedge cluster randomized controlled trial.Randomised trialPLoS Medicine2019Over 5 years oldFull text
- The effects of position on gastric residual volume of premature infants in NICU.Randomised trialItalian Journal of Pediatrics2019Over 5 years oldFull text
- 'Nasal mask' in comparison with 'nasal prongs' or 'rotation of nasal mask with nasal prongs' reduce the incidence of nasal injury in preterm neonates supported on nasal continuous positive airway pressure (nCPAP): A randomized controlled trial.Randomised trialPLoS One2019Over 5 years oldFull text