Guidelines and research

Official guidance for neonatal care, the evidence behind it, and the latest neonatal research.

Open-access systematic reviews, meta-analyses and trials on neonatal topics, chosen for relevance and how widely they are cited. Evidence informs guidance but doesn't replace it.

• Pulmonary Hypertension Association with Mortality in Newborns with Giant Omphalocele: A Systematic Review and Meta-Analysis.Systematic review or meta-analysisNeonatology2026Full text
• The comparative effects of prenatal exposure to methadone versus buprenorphine for opioid use disorder on neonatal outcomes: a systematic review and meta-analysis.Systematic review or meta-analysisBMC Pregnancy and Childbirth2026Full text
• Devices for Neonatal Peripheral Catheterization and Tip Confirmation: A Systematic Review and Meta-Analysis.Systematic review or meta-analysisNeonatology2026Full text
• Optimizing platelet transfusion thresholds in preterm infants: a systematic review and narrative synthesis of impacts on survival and neurodevelopment.Systematic review or meta-analysisBlood Transfusion (journal)2026Full text
• Neonatal Hypoglycemia: A Systematic Review of International and Local Clinical Guidelines with Clinical Implications.Systematic review or meta-analysisJournal of Clinical Medicine2026Full text
• Perioperative outcomes in primary neonatal pullthrough versus pullthrough in older children with Hirschsprung disease: a systematic review and meta-analysis.Systematic review or meta-analysisScientific Reports2026Full text
• Timing of hydrocortisone therapy in neonates with shock: a systematic review, meta-analysis, and clinical practice guideline.Systematic review or meta-analysisFrontiers in Pediatrics2025Full text
• Immediate or early skin-to-skin contact for mothers and their healthy newborn infants.Systematic review or meta-analysisCochrane2025Full text
• Active Treatment vs Expectant Management of Patent Ductus Arteriosus in Preterm Infants: A Meta-Analysis.Systematic review or meta-analysisJAMA Pediatrics2025Full text
• Growth after pediatric and neonatal acute kidney injury: a meta-analysis.Systematic review or meta-analysisPediatric Nephrology (journal)2025Full text
• Comparing Malposition and Complications Associated with Ultrasound-Guided versus Radiography-Guided Central Catheter Tip-Position in Neonates: A Systematic Review and Meta-Analysis.Systematic review or meta-analysisNeonatology2025Full text
• Comprehensive evaluation of risk factors for intraventricular hemorrhage in preterm neonates: a systematic review and meta-analysis.Systematic review or meta-analysisEuropean Journal of Medical Research2025Full text
• Parents', Families', Communities' and Healthcare Professionals' Experiences of Care Following Neonatal Death in Healthcare Facilities in LMICs: A Systematic Review and Meta-Ethnography.Systematic review or meta-analysisBJOG: an international journal of obstetrics and gynaecology2025Full text
• Ethics and end-of-life in pediatric and neonatal ICUs: a systematic review of recommendations.Systematic review or meta-analysisBMC Palliative Care2025Full text
• Inborn errors of metabolism in neonates and pediatrics on varying dialysis modalities: a systematic review and meta-analysis.Systematic review or meta-analysisPediatric Nephrology2025Full text
• Umbilical cord management in newborn resuscitation: a systematic review and meta-analysis.Systematic review or meta-analysisPediatric Research2025Full text
• Evaluation of Newborn Screening for Diseases Using C5-OH as a Marker: Systematic Review of the Literature and Evaluation of 17 Years of C5-OH Screening in the Netherlands.Systematic review or meta-analysisJournal of inherited metabolic disease2025Full text
• Facilitators and barriers to the practice of neonatal family integrated care from the perspective of healthcare professionals: a systematic review.Systematic review or meta-analysisArchives of Disease in Childhood: Fetal and Neonatal Edition2025Full text
• Association between transfer for surgery and mortality and disability among neonates in high income countries-A systematic review with meta-analysis.Systematic review or meta-analysisPLOS ONE2025Full text
• Socioeconomic disparities in the postnatal growth of preterm infants: a systematic review.Systematic review or meta-analysisPediatric Research2025Full text
• Determinants of neonatal mortality in sub-Saharan Africa: systematic review and meta-analysis of adverse newborn conditions.Systematic review or meta-analysisBMC Public Health2025Full text
• Active versus restrictive approach to isolated hypotension in preterm neonates: A Systematic Review, Meta-analysis and GRADE based Clinical Practice Guideline.Systematic review or meta-analysisPLOS ONE2025Full text
• Effectiveness and family experiences of interventions promoting partnerships between families and pediatric and neonatal intensive care units: a mixed methods systematic review.Systematic review or meta-analysisJBI Evidence Synthesis2024Full text
• International treatment outcomes of neonates on extracorporeal membrane oxygenation (ECMO) with persistent pulmonary hypertension of the newborn (PPHN): a systematic review.Systematic review or meta-analysisJournal of Cardiothoracic Surgery2024Full text
• Less invasive surfactant administration versus intubation-surfactant-extubation in the treatment of neonatal respiratory distress syndrome: a systematic review and meta-analyses.Systematic review or meta-analysisJornal de Pediatria2024Full text
• Considerations for Practice in Supporting Parental Bereavement in the Neonatal Intensive Care Unit-a Systematic Review.Systematic review or meta-analysisJournal of Palliative Care2024Full text
• The maternal factors associated with infant low birth weight: an umbrella review.Systematic review or meta-analysisBMC Pregnancy and Childbirth2024Full text
• Neurodevelopmental outcomes in preterm or low birth weight infants with germinal matrix-intraventricular hemorrhage: a meta-analysis.Systematic review or meta-analysisPediatric Research2024Full text
• Eat, Sleep, Console model for neonatal opioid withdrawal syndrome: a meta-analysis.Systematic review or meta-analysisFrontiers in Pediatrics2024Full text
• Factors influencing necrotizing enterocolitis in premature infants in China: a systematic review and meta-analysis.Systematic review or meta-analysisBMC Pediatrics2024Full text
• Inhaled nitric oxide in premature infants for preventing bronchopulmonary dysplasia: a meta-analysis.Systematic review or meta-analysisBMC Pediatrics2023Full text
• A systematic review of associations between gut microbiota composition and growth failure in preterm neonates.Systematic review or meta-analysisGut Microbes2023Full text
• Hemolytic disease of the fetus and newborn: systematic literature review of the antenatal landscape.Systematic review or meta-analysisBMC Pregnancy and Childbirth2023Full text
• A Systematic Review of Clinical Practice Guidelines for Neonatal Abstinence Syndrome.Systematic review or meta-analysisChildren (Basel)2023Full text
• The proportions of term or late preterm births after exposure to early antenatal corticosteroids, and outcomes: systematic review and meta-analysis of 1.6 million infants.Systematic review or meta-analysisBMJ2023Full text
• Preterm birth does not increase the risk of developmental dysplasia of the Hip: a systematic review and meta-analysis.Systematic review or meta-analysisBMC Pediatrics2023Full text
• Short-term neonatal outcomes in women with gestational diabetes treated using metformin versus insulin: a systematic review and meta-analysis of randomized controlled trials.Systematic review or meta-analysisActa diabetologica2023Full text
• Neonatal and long-term outcomes of infants with congenital cytomegalovirus infection and negative amniocentesis: systematic review and meta-analysis.Systematic review or meta-analysisUltrasound in Obstetrics & Gynecology (ISUOG)2023Full text
• Interventions to Reduce Severe Brain Injury Risk in Preterm Neonates: A Systematic Review and Meta-analysis.Systematic review or meta-analysisJAMA Network Open2023Full text
• Impact of peripherally inserted central venous catheter-associated phlebitis in neonate guided by intracavitary electrocardiogram: A systematic review and meta-analysis of randomised controlled trials.Systematic review or meta-analysisInternational Wound Journal2023Full text
• Platelet transfusions in preterm infants: current concepts and controversies-a systematic review and meta-analysis.Systematic review or meta-analysisEuropean Journal of Pediatrics2023Full text
• Adverse maternal, fetal, and newborn outcomes among pregnant women with SARS-CoV-2 infection: an individual participant data meta-analysis.Systematic review or meta-analysisBMJ Global Health2023Full text
• Probiotics to prevent necrotizing enterocolitis and reduce mortality in neonates: A meta-analysis.Systematic review or meta-analysisMedicine (journal)2023Full text
• Clinical practice guidelines for neonatal hypoxic-ischemic encephalopathy: A systematic review using the appraisal of guidelines for research and evaluation (AGREE) II instrument.Systematic review or meta-analysisFrontiers in Pediatrics2023Full text
• A Meta-Analysis of Breastfeeding Effects for Infants With Neonatal Abstinence Syndrome.Systematic review or meta-analysisNursing Research2022Full text
• Incidence of Neonatal Developmental Dysplasia of the Hip and Late Detection Rates Based on Screening Strategy: A Systematic Review and Meta-analysis.Systematic review or meta-analysisJAMA Network Open2022Full text
• Effects of Kangaroo Mother Care in the NICU on the Physiological Stress Parameters of Premature Infants: A Meta-Analysis of RCTs.Systematic review or meta-analysisInternational Journal of Environmental Research and Public Health2022Full text
• Extravasation injury management for neonates and children: A systematic review and aggregated case series.Systematic review or meta-analysisJournal of Hospital Medicine2022Full text
• Effectiveness of universal newborn hearing screening: A systematic review and meta-analysis.Systematic review or meta-analysisJournal of Global Health2022Full text
• Therapeutic hypothermia in neonatal hypoxic encephalopathy: A systematic review and meta-analysis.Systematic review or meta-analysisJournal of Global Health2022Full text
• Diagnostic accuracy of ultrasound for localising peripherally inserted central catheter tips in infants in the neonatal intensive care unit: a systematic review and meta-analysis.Systematic review or meta-analysisPediatric Radiology2022Full text
• A systematic review of newborn and childhood hearing screening around the world: comparison and quality assessment of guidelines.Systematic review or meta-analysisBMC Pediatrics2022Full text
• Protocol and programme factors associated with referral and loss to follow-up from newborn hearing screening: a systematic review.Systematic review or meta-analysisBMC Pediatrics2022Full text
• Preterm Brain Injury and Neurodevelopmental Outcomes: A Meta-analysis.Systematic review or meta-analysisPediatrics2022Full text
• Fish oil-containing lipid emulsions prevention on parenteral nutrition-associated cholestasis in very low birth weight infants: a meta-analysis.Systematic review or meta-analysisWorld Journal of Pediatrics2022Full text
• Serum Cystatin C as a predictor of acute kidney injury in neonates: a meta-analysis.Systematic review or meta-analysisJornal de Pediatria2022Full text
• Serum and urinary biomarkers to predict acute kidney injury in premature infants: a systematic review and meta-analysis of diagnostic accuracy.Systematic review or meta-analysisJournal of Nephrology2022Full text
• Nurses' strategies to provide emotional and practical support to the mothers of preterm infants in the neonatal intensive care unit: A systematic review and meta-analysis.Systematic review or meta-analysisWomen's Health (London, England)2022Full text
• The incidence and mortality rate of catheter-related neonatal pericardial effusion: A meta-analysis.Systematic review or meta-analysisMedicine2022Full text
• Efficacy of Donated Milk in Early Nutrition of Preterm Infants: A Meta-Analysis.Systematic review or meta-analysisNutrients2022Full text